Target Product Profiles for Tuberculosis Preventive Treatment

Tuberculosis (TB) is a major yet preventable global health problem, with an estimated 10 million people developing TB and 1.5 million people dying every year worldwide, making it the leading infectious disease cause of death worldwide. One quarter of the global population is estimated to be infected with Mycobacterium tuberculosis. Treatment of TB infection, also known as TB preventive treatment (TPT), aims to prevent the development of TB disease, and is one of the critical components to achieve the ambitious targets of the WHO End TB Strategy. At the United Nations High-level Meeting on TB in 2018, countries committed to provide TPT to at least 30 million people in 2018-2022.